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公开(公告)号：EP1648475B1
公开(公告)日：2007-09-12
申请号：EP04777982.2
申请日：2004-07-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSITY OF ALABAMA RESEARCH FOUNDATION , LOMA LINDA UNIVERSITY , WAKE FOREST UNIVERSITY
发明人： GLADWIN, Mark, T. , SCHECHTER, Alan, N. , LEFER, David, J. , PATEL, Rakesh, P. , HUNTER, Christian J., National Inst. of Health , POWER, Gordon, G. , KIM-SHAPIRO, Daniel, B. , PLUTA, Ryszard National Institutes of Health NINDS , OLDFIELD, Edward, H. , CANNON III, Richard, O.
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
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公开(公告)号：EP1648475A2
公开(公告)日：2006-04-26
申请号：EP04777982.2
申请日：2004-07-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSITY OF ALABAMA RESEARCH FOUNDATION , LOMA LINDA UNIVERSITY , WAKE FOREST UNIVERSITY
发明人： GLADWIN, Mark, T. , SCHECHTER, Alan, N. , LEFER, David, J. , PATEL, Rakesh, P. , HUNTER, Christian J., National Inst. of Health , POWER, Gordon, G. , KIM-SHAPIRO, Daniel, B. , PLUTA, Ryszard National Institutes of Health NINDS , OLDFIELD, Edward, H.
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
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公开(公告)号：EP1551292A2
公开(公告)日：2005-07-13
申请号：EP03756863.1
申请日：2003-09-24
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61B6/508 , A61K9/0085 , A61K49/0438 , A61K49/085 , A61K49/124 , A61K49/14 , G01R33/56308 , Y02A90/26
摘要： A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.
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