发明公开
- 专利标题： VIRAL POLYMERASE INHIBITORS
- 专利标题（中）： 病毒聚合酶抑制剂
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申请号： EP05768261.9申请日： 2005-07-15
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公开(公告)号： EP1771442A1公开(公告)日： 2007-04-11
- 发明人: BEAULIEU, Pierre, L. , BROCHU, Christian , KAWAI, Stephen , RANCOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , TSANTRIZOS, Youla, S.
- 申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
- 申请人地址： Binger Strasse 173 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim DE
- 代理机构： Hammann, Heinz
- 优先权： US588670P 20040716
- 国际公布： WO2006007693 20060126
- 主分类号： C07D417/04
- IPC分类号： C07D417/04 ; A61P31/14 ; A61K31/4439 ; A61K31/506 ; A61K31/497 ; A61K31/4155 ; A61K31/404 ; A61K31/427 ; C07D209/42 ; C07D401/04 ; C07D403/04 ; C07D405/04 ; C07D409/04
摘要：
A compound, represented by formula (I) or an enantiomer, diastereoisomer or tautomer thereof : wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or a salt, ester or derivative thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particulary those viral polymerases within the Flaviviridae family, more particulary to HCV polymerase.
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