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公开(公告)号：EP1771442A1
公开(公告)日：2007-04-11
申请号：EP05768261.9
申请日：2005-07-15
发明人： BEAULIEU, Pierre, L. , BROCHU, Christian , KAWAI, Stephen , RANCOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , TSANTRIZOS, Youla, S.
IPC分类号： C07D417/04 , A61P31/14 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/4155 , A61K31/404 , A61K31/427 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
CPC分类号： C07D403/04 , C07D209/08 , C07D209/12 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04
摘要： A compound, represented by formula (I) or an enantiomer, diastereoisomer or tautomer thereof : wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R5, R6, R7, R9, and R10 are as defined herein, or a salt, ester or derivative thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particulary those viral polymerases within the Flaviviridae family, more particulary to HCV polymerase.
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公开(公告)号：EP1718608A1
公开(公告)日：2006-11-08
申请号：EP05714457.8
申请日：2005-02-18
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D201/00
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.
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公开(公告)号：EP1718608B1
公开(公告)日：2013-07-17
申请号：EP05714457.8
申请日：2005-02-18
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
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公开(公告)号：EP2019825B9
公开(公告)日：2011-01-26
申请号：EP07784947.9
申请日：2007-05-14
发明人： TSANTRIZOS, Youla, S. , BOES, Michael , BROCHU, Christian , FENWICK, Craig , MALENFANT, Eric , MASON, Stephen , PESANT, Marc
IPC分类号： C07D311/08 , A61K31/352 , A61K31/47 , A61P31/18 , C07D215/22 , C07D215/14 , C07D215/18 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12 , C07D215/227
CPC分类号： C07D215/22 , C07D215/14 , C07D215/18 , C07D215/227 , C07D311/08 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12
摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：EP2019825B1
公开(公告)日：2010-09-01
申请号：EP07784947.9
申请日：2007-05-14
发明人： TSANTRIZOS, Youla, S. , BOES, Michael , BROCHU, Christian , FENWICK, Craig , MALENFANT, Eric , MASON, Stephen , PESANT, Marc
IPC分类号： C07D311/08 , A61K31/352 , A61K31/47 , A61P31/18 , C07D215/22 , C07D215/14 , C07D215/18 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12 , C07D215/227
CPC分类号： C07D215/22 , C07D215/14 , C07D215/18 , C07D215/227 , C07D311/08 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12
摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：EP2019825A1
公开(公告)日：2009-02-04
申请号：EP07784947.9
申请日：2007-05-14
发明人： TSANTRIZOS, Youla, S. , BOES, Michael , BROCHU, Christian , FENWICK, Craig , MALENFANT, Eric , MASON, Stephen , PESANT, Marc
IPC分类号： C07D311/08 , A61K31/352 , A61K31/47 , A61P31/18 , C07D215/22
CPC分类号： C07D215/22 , C07D215/14 , C07D215/18 , C07D215/227 , C07D311/08 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12
摘要： The invention relates to compounds of formula (I) their derivatives comprising a detectable label, their compositions and their use in the treatment of human immunodeficiency virus (HIV) infection. In particular, the invention provides novel inhibitors of HIV replication, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：EP1587787A1
公开(公告)日：2005-10-26
申请号：EP04703130.7
申请日：2004-01-19
发明人： BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Catherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
IPC分类号： C07D209/08 , C07D405/04 , C07D405/14 , C07D401/06 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , C07D401/04 , C07D413/14 , C07D513/04 , C07D209/30 , A61K31/404 , A61P31/12
CPC分类号： C07D401/04 , C07D209/08 , C07D209/30 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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公开(公告)号：EP2477976A1
公开(公告)日：2012-07-25
申请号：EP10816523.4
申请日：2010-09-16
发明人： STAMMERS, Timothy , BARBEAU, Xavier , BEAULIEU, Pierre , BERTRAND-LAPERLE, Megan , BROCHU, Christian , EDWARDS, Paul, J. , FORGIONE, Pasquale , GODBOUT, Cédrickx , HUCKE, Oliver , JOLY, Marc-André , LANDRY, Serge , LEPAGE, Olivier , NAUD, Julie , PESANT, Marc , POIRIER, Martin , POIRIER, Maude , THAVONEKHAM, Bounkham
IPC分类号： C07D401/12 , A61K31/517 , A61K31/14 , C07C211/29 , C07C233/13 , C07C237/44 , C07C251/48 , C07C255/58 , C07D213/74 , C07D239/42 , C07D239/88 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07F5/02
CPC分类号： C07D401/12 , A61K31/14 , A61K31/517 , C07C211/29 , C07C233/11 , C07C237/44 , C07C251/48 , C07C255/58 , C07C255/59 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07F5/025
摘要： Compounds of formula I: (I) wherein X, R
2 , R
3 , R
5 and R
6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.-
公开(公告)号：EP2748160A1
公开(公告)日：2014-07-02
申请号：EP12825872.0
申请日：2012-08-22
发明人： BROCHU, Christian , GRAND-MAÎTRE, Chantal , FADER, Lee , KUHN, Cyrille , BERTRAND-LAPERLE, Mégan , PESANT, Marc
IPC分类号： C07D403/14 , A61K31/395 , A61K31/403 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/519 , A61P31/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC分类号： C07D471/04 , A61K31/403 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I) useful for the treatment or prevention of hepatitis C viral infection, (Formula (I)) wherein: X
1 and X
2 are each independently CR
B or N; R
B is H, (C
1-6 )alkyl, (C
1-6 )haloalkyl, halo. -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; R
1 and R
2 are each independently (C
1-6 )alkyl optionally mono- or di-substituted with -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; or R
1 and R
2 , together with the carbon to which they are attached, are linked to form a (C
3-7 )cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with -(C
1-6 )alkyl; R
A is -C(=O)N(R
3 )(R
4 ), -C(=O)O(R
4 ), heterocyclyl or heteroaryl, wherein each said heterocyclyl and heteroaryl is optionally substituted 1 to 3 times with R
41 ; R
5 and R
6 are each independently H or (C
1-6 )alkyl optionally mono- or di-substituted with -O-(C
1-6 )alkyl, NH
2 , NH(C
1-6 )alkyl or N((C
1-6 )alkyl)
2 ; or R
5 and R
6 , together with the carbon to which they are attached, are linked to form a (C
3-7 )cycloalkyl group or a 3- to 7-membered heterocyclyl, said cycloalkyl and heterocyclyl being optionally mono- or di-substituted with -(C
1-6 )alkyl; and n is 0, 1 or 2.-
公开(公告)号：EP3328859B1
公开(公告)日：2020-06-03
申请号：EP16830925.0
申请日：2016-07-28
发明人： AYESA, Susana , ERSMARK, Karolina , KALAYANOV, Gennadiy , LEIJONMARCK, Marie , SALVADOR ODEN, Lourdes , WESTERLIND, Hans , WÄHLING, Horst , BERTRAND, Megan , BROCHU, Christian , GHIRO, Elise , KUHN, Cyrille , STURINO, Claudio , BYLUND, Johan , SEHGELMEBLE, Fernando
IPC分类号： C07D471/04 , C07D471/10 , C07D471/20 , C07D487/10 , C07D401/06 , C07D401/14 , C07D403/14 , A61K31/4725 , A61P31/14
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