发明公开
EP2123668A1 Immunogenic polypeptides that mimic the surface polysaccharide O-antigen from serotype 2A shigella flexneri, method for obtaining the same, and their use in vaccine and diagnostic compositions
审中-公开
模拟血清型2A痢疾杆菌的表面多糖O-抗原的免疫原性多肽，它们的制备方法以及它们在疫苗和诊断组合物中使用
- 专利标题： Immunogenic polypeptides that mimic the surface polysaccharide O-antigen from serotype 2A shigella flexneri, method for obtaining the same, and their use in vaccine and diagnostic compositions
- 专利标题（中）： 模拟血清型2A痢疾杆菌的表面多糖O-抗原的免疫原性多肽，它们的制备方法以及它们在疫苗和诊断组合物中使用
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申请号： EP08290476.4申请日： 2008-05-22
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公开(公告)号： EP2123668A1公开(公告)日： 2009-11-25
- 发明人: Mulard, Laurence , Phalipon, Armelle , Vulliez-Le Normand, Brigitte , Theillet, François-Xavier , Bentley, Graham , Saul, Frederick , Delepierre, Murielle , Felici, Franco
- 申请人： INSTITUT PASTEUR
- 申请人地址： 25-28, rue du Docteur-Roux F-75015 Paris FR
- 专利权人： INSTITUT PASTEUR
- 当前专利权人： INSTITUT PASTEUR
- 当前专利权人地址： 25-28, rue du Docteur-Roux F-75015 Paris FR
- 代理机构： Warcoin, Jacques
- 主分类号： C07K11/00
- IPC分类号： C07K11/00 ; C07K14/00 ; A61K39/112 ; A61P31/04
摘要：
The present invention is directed to purified immunogenic polypeptides comprising an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for the O-antigen from serotype 2a Shigella flexneri. The invention also concerns the use of said purified immunogenic polypeptides for the preparation of vaccine against serotype 2a S . flexneri infection and for the preparation of diagnostic compositions for the detection of serotype 2a S . flexneri infection. Finally, the present invention comprises high-resolution crystal structures of said natural O-antigen, or functional fragments thereof, possibly synthetic, and a the mimetic peptide, in complex with a protective monoclonal antibody, or functional fragments thereof, and to methods for selecting immunogenic polypeptides for the preparation of new candidate vaccinal compositions based on said crystals.
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