发明授权
EP2190469B1 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
有权
多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
- 专利标题： POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
- 专利标题（中）： 多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
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申请号： EP08829443.4申请日： 2008-09-03
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公开(公告)号： EP2190469B1公开(公告)日： 2015-02-25
- 发明人: LEVINE, Zurit , ROSENBERG, Avi , ROTMAN, Galit , NOVIK, Amit , TOPORIK, Amir , KINAR, Yaron , NEMZER, Sergey , KOIFMAN, Cynthia , BEIMAN, Merav , DASSA, Liat , WALACH, Shira , MONTIA, Eve , SAMEACH-GREENWALD, Shirley , PERGAM, Tania , MILO, Dalit , COHEN-DAYAG, Anat , LEVY, Ofer , BUBIS, Marina
- 申请人： Compugen Ltd.
- 申请人地址： Pinchas Rosen Street 72 69512 Tel Aviv IL
- 专利权人： Compugen Ltd.
- 当前专利权人： Compugen Ltd.
- 当前专利权人地址： Pinchas Rosen Street 72 69512 Tel Aviv IL
- 代理机构： Fuchs Patentanwälte Partnerschaft mbB
- 优先权： US969865P 20070904; US969799P 20070904; US969780P 20070904; US969806P 20070904; US969769P 20070904; US969788P 20070904
- 国际公布： WO2009032845 20090312
- 主分类号： A61K39/00
- IPC分类号： A61K39/00
摘要：
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.
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