发明公开
- 专利标题： ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
- 专利标题（中）： 非甾体类消炎药抗生素结合物
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申请号： EP14710781.7申请日： 2014-03-06
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公开(公告)号： EP2964265A1公开(公告)日： 2016-01-13
- 发明人: SINHA, Santosh C. , CHOW, Ken , BHAT, Smita S. , WANG, Liming , SWIFT, Brandon D. , ATTAR, Mayssa , GARST, Michael E.
- 申请人： ALLERGAN, INC.
- 申请人地址： 2525 Dupont Drive Irvine, CA 92612 US
- 专利权人： ALLERGAN, INC.
- 当前专利权人： ALLERGAN, INC.
- 当前专利权人地址： 2525 Dupont Drive Irvine, CA 92612 US
- 代理机构： Hoffmann Eitle
- 优先权： US201361775199P 20130308
- 国际公布： WO2014138343 20140912
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61P27/02 ; A61P29/00 ; A61P31/04
摘要：
The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug.
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