公开(公告)号：EP2964265A1

公开(公告)日：2016-01-13

申请号：EP14710781.7

申请日：2014-03-06

申请人： ALLERGAN, INC.

发明人： SINHA, Santosh C. ,  CHOW, Ken ,  BHAT, Smita S. ,  WANG, Liming ,  SWIFT, Brandon D. ,  ATTAR, Mayssa ,  GARST, Michael E.

IPC分类号： A61K47/48 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04

CPC分类号： A61K47/48115 ,  A61K47/552 ,  C07D309/14 ,  C07D405/14 ,  C07D487/04 ,  C07H15/234

摘要： The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug.

公开(公告)号：EP2643303A1

公开(公告)日：2013-10-02

申请号：EP11785261.6

申请日：2011-11-10

申请人： Allergan, Inc.

发明人： SINHA, Santosh C. ,  BHAT, Smita S. ,  CHOW, Ken ,  GARST, Michael E. ,  IM, Wha Bin

IPC分类号： C07D233/60 ,  C07D233/61 ,  C07D295/03 ,  A61K31/40 ,  A61P37/06 ,  A61P25/28 ,  A61P25/02 ,  A61P29/00 ,  A61P9/10 ,  A61P29/02

CPC分类号： C07D233/61 ,  C07D233/60

摘要： The present invention relates to novel diphenylethyne derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

公开(公告)号：EP2964268A1

公开(公告)日：2016-01-13

申请号：EP14712952.2

申请日：2014-03-06

申请人： ALLERGAN, INC.

发明人： SINHA, Santosh C. ,  CHOW, Ken ,  WANG, Liming ,  BHAT, Smita S. ,  SWIFT, Brandon D. ,  ATTAR, Mayssa ,  GARST, Michael E.

IPC分类号： A61K47/48 ,  A61P31/04 ,  A61P27/00

CPC分类号： A61K47/48115 ,  A61K9/0048 ,  A61K47/481 ,  A61K47/48123 ,  A61K47/48246 ,  A61K47/55 ,  A61K47/554 ,  A61K47/64 ,  C07K7/645

摘要： The present invention describes antibiotic conjugates. These single drug entities are formed connecting one antibiotic with another antibiotic. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.

公开(公告)号：EP2646415A1

公开(公告)日：2013-10-09

申请号：EP11794322.5

申请日：2011-11-28

申请人： Allergan, Inc.

发明人： SINHA, Santosh C. ,  BHAT, Smita S. ,  CORPUZ, Evelyn G. ,  CHOW, Ken ,  FANG, Wenkui K. ,  IM, Wha Bin

IPC分类号： C07D205/04 ,  A61K31/397 ,  A61P27/02 ,  A61P11/00 ,  A61P25/00 ,  A61P17/00 ,  A61P9/00 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D205/04

摘要： The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

摘要翻译： 本发明涉及新型氮杂环丁烷衍生物，其制备方法，含有它们的药物组合物以及它们作为药物用作鞘氨醇-1-磷酸受体调节剂的用途。

公开(公告)号：EP2964267A1

公开(公告)日：2016-01-13

申请号：EP14712948.0

申请日：2014-03-06

申请人： ALLERGAN, INC.

发明人： SINHA, Santosh C. ,  CHOW, Ken ,  WANG, Liming ,  BHAT, Smita S. ,  SWIFT, Brandon D. ,  ATTAR, Mayssa ,  GARST, Michael E.

IPC分类号： A61K47/48 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  C07D215/56

CPC分类号： A61K47/48115 ,  A61K9/0048 ,  A61K47/552 ,  A61K47/554 ,  C07J41/005 ,  C07J43/003

摘要： The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.

公开(公告)号：EP2643297A1

公开(公告)日：2013-10-02

申请号：EP11787988.2

申请日：2011-11-10

申请人： Allergan, Inc.

发明人： SINHA, Santosh C. ,  BHAT, Smita S. ,  CHOW, Ken ,  GARST, Michael E. ,  IM, Wha Bin

IPC分类号： C07D209/42 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  A61K31/4245 ,  A61K31/405 ,  A61K31/443 ,  A61P27/02 ,  A61P9/10 ,  A61P17/02 ,  A61P19/00 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00

CPC分类号： C07D413/14 ,  C07D209/42 ,  C07D403/12 ,  C07D413/04

摘要： The present invention relates to novel indole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.