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公开(公告)号：EP2964268A1
公开(公告)日：2016-01-13
申请号：EP14712952.2
申请日：2014-03-06
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh C. , CHOW, Ken , WANG, Liming , BHAT, Smita S. , SWIFT, Brandon D. , ATTAR, Mayssa , GARST, Michael E.
CPC分类号： A61K47/48115 , A61K9/0048 , A61K47/481 , A61K47/48123 , A61K47/48246 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes antibiotic conjugates. These single drug entities are formed connecting one antibiotic with another antibiotic. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
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2.发明公开KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN 有权KETOROLAC-TROMETHAMIN-ZUSAMMENSETZUNGEN ZUR BEHANDLUNG ODER PRENVENTION VON SCHMERZ
公开(公告)号：EP2473157A1
公开(公告)日：2012-07-11
申请号：EP10754617.8
申请日：2010-08-31
申请人： Allergan, Inc.
发明人： FARNES, Eldon Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett M. , CHANG, Chin-Ming , GRAHAM, Richard S. , WELTY, Devin
IPC分类号： A61K9/00 , A61K47/38 , A61K31/407
CPC分类号： A61K31/407 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution which provides increased visual acuity in users and wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient which is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
摘要翻译： 本发明提供了在水溶液中具有有效量的酮咯酸和羧甲基纤维素的水性眼用溶液，其提供增加的视敏度，并且其中选择羧甲基纤维素的浓度以提供在患者的眼睛中增加酮咯酸的吸收， 比具有相同浓度的酮咯酸的对比水性酮咯酸眼药液的吸收大至少130％。
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公开(公告)号：EP2779992B1
公开(公告)日：2018-02-28
申请号：EP12788092.0
申请日：2012-11-14
申请人： ALLERGAN, INC.
发明人： BLANDA, Wendy M. , ATTAR, Mayssa
CPC分类号： A61K38/13 , A61K9/0019 , A61K9/0048 , A61K47/32 , A61K47/36 , A61K47/38 , C07K1/306 , C07K7/645
摘要： Disclosed herein are methods of treating diseases of the eye by administering to the subconjunctival space a formulation comprising cyclosporin A form 2 and a hydrogel.
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公开(公告)号：EP2964265A1
公开(公告)日：2016-01-13
申请号：EP14710781.7
申请日：2014-03-06
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh C. , CHOW, Ken , BHAT, Smita S. , WANG, Liming , SWIFT, Brandon D. , ATTAR, Mayssa , GARST, Michael E.
CPC分类号： A61K47/48115 , A61K47/552 , C07D309/14 , C07D405/14 , C07D487/04 , C07H15/234
摘要： The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug.
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5.发明公开KETOROLAC COMPOSITIONS FOR CORNEAL WOUND HEALING 有权KETOROLAC-ZUSAMMENSETZUNGEN ZUR ABHEILUNG VON HORNHAUTWUNDEN
公开(公告)号：EP2555770A1
公开(公告)日：2013-02-13
申请号：EP11715353.6
申请日：2011-04-06
申请人： Allergan, Inc.
发明人： GRAHAM, Richard, S. , HOLLANDER, David , VILLANUEVA, Linda , FARNES, Eldon, Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett, M. , CHANG, Chin-Ming , WELTY, Devin, F.
IPC分类号： A61K31/407 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/407 , A61K47/38
摘要： The present invention is directed to an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose which promotes epithelial wound healing in a patients cornea.
摘要翻译： 本发明涉及一种含有有效量的酮咯酸的水性眼用溶液，其包含促进患者角膜上皮创面愈合的羧甲基纤维素。
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7.发明授权
公开(公告)号：EP2257275B1
公开(公告)日：2011-12-28
申请号：EP09716497.4
申请日：2009-03-03
申请人： Allergan, Inc.
发明人： FARNES, Eldon Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett M. , CHANG, Chin-ming , GRAHAM, Richard S. , WELTY, Devin F.
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/407 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
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8.发明公开
公开(公告)号：EP2257275A2
公开(公告)日：2010-12-08
申请号：EP09716497.4
申请日：2009-03-03
申请人： Allergan, Inc.
发明人： FARNES, Eldon Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett M. , CHANG, Chin-ming , GRAHAM, Richard S. , WELTY, Devin F.
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/407 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
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9.发明授权
公开(公告)号：EP2473157B1
公开(公告)日：2017-11-15
申请号：EP10754617.8
申请日：2010-08-31
申请人： ALLERGAN, INC.
发明人： FARNES, Eldon Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett M. , CHANG, Chin-Ming , GRAHAM, Richard S. , WELTY, Devin
IPC分类号： A61K9/00 , A61K47/38 , A61K31/407
CPC分类号： A61K31/407 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
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公开(公告)号：EP2555770B1
公开(公告)日：2017-11-01
申请号：EP11715353.6
申请日：2011-04-06
申请人： ALLERGAN, INC.
发明人： GRAHAM, Richard, S. , HOLLANDER, David , VILLANUEVA, Linda , FARNES, Eldon, Quinn , ATTAR, Mayssa , SCHIFFMAN, Rhett, M. , CHANG, Chin-Ming , WELTY, Devin, F.
IPC分类号： A61K31/407 , A61P27/02 , A61K9/00 , A61K9/08 , A61K47/38
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/407 , A61K47/38
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