Invention Patent
- Patent Title: NOVEL PEPTIDASE INHIBITOR
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Application No.: JP2137186Application Date: 1986-02-04
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Publication No.: JPS61183253APublication Date: 1986-08-15
- Inventor: MAIKERU KORUBU , MAIKERU JIEI JIYANGU , JIYOSEFU PII BURUKAATO , FURITSUTSU II GEEHAATO , YUUJIN ERU GIROTSUKUSU , DANIERU JII SUCHIRURIN , BAANAADO NEISESU
- Applicant: MERRELL DOW PHARMA
- Assignee: MERRELL DOW PHARMA
- Current Assignee: MERRELL DOW PHARMA
- Priority: US69798785 1985-02-04
- Main IPC: C07K5/00
- IPC: C07K5/00 ; A61K31/13 ; A61K31/16 ; A61K31/165 ; A61K31/195 ; A61K31/215 ; A61K31/22 ; A61K38/00 ; A61K38/55 ; A61P7/02 ; A61P7/06 ; A61P9/12 ; A61P13/02 ; A61P15/00 ; A61P17/00 ; A61P29/00 ; A61P31/04 ; A61P35/00 ; A61P43/00 ; C07C67/00 ; C07C213/00 ; C07C221/00 ; C07C225/02 ; C07C225/16 ; C07C227/00 ; C07C227/16 ; C07C227/18 ; C07C229/02 ; C07C229/04 ; C07C229/22 ; C07C229/24 ; C07C229/26 ; C07C233/01 ; C07C233/31 ; C07C237/02 ; C07C237/06 ; C07C237/12 ; C07C237/20 ; C07C237/22 ; C07C239/00 ; C07C271/06 ; C07C271/22 ; C07C273/04 ; C07C279/18 ; C07D207/16 ; C07D209/42 ; C07D498/10 ; C07K1/113 ; C07K5/02 ; C07K5/04 ; C07K5/06 ; C07K5/062 ; C07K5/08 ; C07K5/083 ; C07K5/097 ; C07K7/06 ; C07K14/81 ; C12N9/99
Abstract:
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
Public/Granted literature
- JP2529825B2 Public/Granted day:1996-09-04
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