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公开(公告)号：JP2529825B2
公开(公告)日：1996-09-04
申请号：JP2137186
申请日：1986-02-04
申请人： MERRELL DOW PHARMA
发明人： MAIKERU KORUBU , MAIKERU JEI JANGU , JOSEFU PII BURUKAATO , FURITSUTSU II GEEHAATO , YUUJIN ERU GIROTSUKUSU , DANIERU JII SUCHIRURIN , BAANAADO NEISESU
IPC分类号： C07K5/00 , A61K31/13 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61K38/00 , A61K38/55 , A61P7/02 , A61P7/06 , A61P9/12 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07C67/00 , C07C213/00 , C07C221/00 , C07C225/02 , C07C225/16 , C07C227/00 , C07C227/16 , C07C227/18 , C07C229/02 , C07C229/04 , C07C229/22 , C07C229/24 , C07C229/26 , C07C233/01 , C07C233/31 , C07C237/02 , C07C237/06 , C07C237/12 , C07C237/20 , C07C237/22 , C07C239/00 , C07C271/06 , C07C271/22 , C07C273/04 , C07C279/18 , C07D207/16 , C07D209/42 , C07D498/10 , C07K1/113 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/062 , C07K5/08 , C07K5/083 , C07K5/097 , C07K7/06 , C07K14/81 , C12N9/99
摘要： This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
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公开(公告)号：JP2520244B2
公开(公告)日：1996-07-31
申请号：JP422587
申请日：1987-01-13
申请人： MERRELL DOW PHARMA
IPC分类号： C12N9/99 , A61K20060101 , A61K31/13 , A61P17/00 , A61P35/00 , A61P43/00 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/14 , C07C209/16 , C07C209/62 , C07C211/23 , C07C211/24 , C07C229/40 , C07F20060101 , C07F13/00
摘要： Novel fluorinated diaminoalkyne derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general formula I:wherein R represents C 1 - C 4 alkyl, or preferably, hydrogen.
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公开(公告)号：JPS61183253A
公开(公告)日：1986-08-15
申请号：JP2137186
申请日：1986-02-04
申请人： MERRELL DOW PHARMA
发明人： MAIKERU KORUBU , MAIKERU JIEI JIYANGU , JIYOSEFU PII BURUKAATO , FURITSUTSU II GEEHAATO , YUUJIN ERU GIROTSUKUSU , DANIERU JII SUCHIRURIN , BAANAADO NEISESU
IPC分类号： C07K5/00 , A61K31/13 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61K38/00 , A61K38/55 , A61P7/02 , A61P7/06 , A61P9/12 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07C67/00 , C07C213/00 , C07C221/00 , C07C225/02 , C07C225/16 , C07C227/00 , C07C227/16 , C07C227/18 , C07C229/02 , C07C229/04 , C07C229/22 , C07C229/24 , C07C229/26 , C07C233/01 , C07C233/31 , C07C237/02 , C07C237/06 , C07C237/12 , C07C237/20 , C07C237/22 , C07C239/00 , C07C271/06 , C07C271/22 , C07C273/04 , C07C279/18 , C07D207/16 , C07D209/42 , C07D498/10 , C07K1/113 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/062 , C07K5/08 , C07K5/083 , C07K5/097 , C07K7/06 , C07K14/81 , C12N9/99
摘要： This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
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公开(公告)号：JPS62197144A
公开(公告)日：1987-08-31
申请号：JP30899386
申请日：1986-12-26
申请人： MERRELL DOW PHARMA
IPC分类号： C07C41/24 , B01J19/00 , B01J19/18 , B01J19/24 , C07C41/00 , C07C43/17 , C07C67/00 , C07C69/65 , C07C253/00 , C07C255/25 , C07C255/30
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公开(公告)号：JPS62167744A
公开(公告)日：1987-07-24
申请号：JP422587
申请日：1987-01-13
申请人： MERRELL DOW PHARMA
IPC分类号： C12N9/99 , A61K20060101 , A61K31/13 , A61P17/00 , A61P35/00 , A61P43/00 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/14 , C07C209/16 , C07C209/62 , C07C211/23 , C07C211/24 , C07C229/40 , C07F20060101 , C07F13/00
摘要： Novel fluorinated diaminoalkyne derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general formula I:wherein R represents C 1 - C 4 alkyl, or preferably, hydrogen.
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