- 专利标题： Microbial approach for the production of 5-hydroxytryptophan
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申请号： US15310040申请日： 2015-05-14
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公开(公告)号： US10023889B2公开(公告)日： 2018-07-17
- 发明人: Yajun Yan , Yuheng Lin
- 申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- 申请人地址： US GA Athens
- 专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人地址： US GA Athens
- 代理机构： Mueting, Raasch & Gebhardt, P.A.
- 国际申请： PCT/US2015/030811 WO 20150514
- 国际公布： WO2015/175793 WO 20151119
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12P13/22 ; C12N9/02 ; C12N9/88 ; C12N9/06 ; A23L2/52 ; A23K20/10
摘要：
5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
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