Invention Grant
- Patent Title: Efficient process of asymmetric hydrogenation of unsaturated ketones using additives
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Application No.: US14651505Application Date: 2013-12-18
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Publication No.: US10047019B2Publication Date: 2018-08-14
- Inventor: Jonathan Alan Medlock , Gerardus Karel Maria Verzijl , Edwin Gerard Ijpeij , Andreas Hendrikus Maria De Vries
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP12197791 20121218
- International Application: PCT/IB2013/061081 WO 20131218
- International Announcement: WO2014/097170 WO 20140626
- Main IPC: C07C45/62
- IPC: C07C45/62 ; C07B35/02 ; C07D311/72 ; C07B53/00
Abstract:
The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
Public/Granted literature
- US20150321971A1 EFFICIENT PROCESS OF ASYMMETRIC HYDROGENATION OF UNSATURATED KETONES USING ADDITIVES Public/Granted day:2015-11-12
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