公开(公告)号：US10047019B2

公开(公告)日：2018-08-14

申请号：US14651505

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Jonathan Alan Medlock ,  Gerardus Karel Maria Verzijl ,  Edwin Gerard Ijpeij ,  Andreas Hendrikus Maria De Vries

IPC: C07C45/62 ,  C07B35/02 ,  C07D311/72 ,  C07B53/00

Abstract: The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.