Embodiments of systems and methods for selectively enabling and disabling protocols of a USB-C port are provided herein. According to one embodiment, a method for selectively enabling one or more protocols of a USB-C port on an information handling system (IHS) includes determining, upon system boot, if the IHS is connected via the USB-C port to a peripheral device that is authorized for use with the information handling system. If the peripheral device is not authorized for use with the IHS, the method may disable all protocols of the USB-C port. If the peripheral device is authorized for use with the IHS, the method may enable one or more protocols of the USB-C port.