Means and methods for producing high affinity antibodies

Invention Grant

US10344076B2 Means and methods for producing high affinity antibodies 有权

Patent Title: Means and methods for producing high affinity antibodies
Application No.: US15048339

Application Date: 2016-02-19
Publication No.: US10344076B2

Publication Date: 2019-07-09
Inventor: Tim Beaumont , Mark Jeroen Kwakkenbos , Hergen Spits , Adrianus Quirinus Bakker
Applicant: AIMM THERAPEUTICS B.V.
Applicant Address: NL Amsterdam
Assignee: AIMM THERAPEUTICS B.V.
Current Assignee: AIMM THERAPEUTICS B.V.
Current Assignee Address: NL Amsterdam
Agency: Saul Ewing Arnstein & Lehr LLP
Agent Gianna Julian-Arnold
Priority: EP09165603 20090715
Main IPC: C12N15/63
IPC: C12N15/63 ; C12N15/06 ; A61K38/00 ; C07K17/00 ; C07K16/10 ; C07K16/00

Abstract:

The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N15/00	突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主（突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00；新的植物入A01H；用组织培养技术再生植物入A01H4/00；新的动物入A01K67/00；含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用，基因疗法入A61K48/00，一般肽入C07K）
C12N15/09	.DNA重组技术
C12N15/63	..使用载体引入外来遗传物质；载体；其宿主的使用；表达的调节