公开(公告)号：US09969795B2

公开(公告)日：2018-05-15

申请号：US14956919

申请日：2015-12-02

Applicant: AIMM THERAPEUTICS B.V.

Inventor： Tim Beaumont ,  Mark Jeroen Kwakkenbos ,  Hergen Spits ,  Adrianus Quirinus Bakker ,  Koen Wagner

IPC: C07K16/00 ,  C07K16/10 ,  C07K14/47

CPC classification number: C07K16/1018 ,  C07K14/4703 ,  C07K14/4747 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

Abstract: The invention provides means and methods for producing high-affinity antibodies against an antigen of interest, usually stable B-cell cultures.

公开(公告)号：US10556963B2

公开(公告)日：2020-02-11

申请号：US15105076

申请日：2014-12-17

Applicant: AIMM Therapeutics B.V.

Inventor： Hergen Spits ,  Tim Beaumont ,  Marijn Aletta Gillissen ,  Adrianus Quirinus Bakker ,  Mette Deborah Hazenberg ,  Martijn Kedde

IPC: C07K16/30 ,  C07K16/06 ,  A61K47/68 ,  C07K16/40 ,  C12P21/00 ,  G01N33/574

Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.

公开(公告)号：US10344076B2

公开(公告)日：2019-07-09

申请号：US15048339

申请日：2016-02-19

Applicant: AIMM THERAPEUTICS B.V.

Inventor： Tim Beaumont ,  Mark Jeroen Kwakkenbos ,  Hergen Spits ,  Adrianus Quirinus Bakker

IPC: C12N15/63 ,  C12N15/06 ,  A61K38/00 ,  C07K17/00 ,  C07K16/10 ,  C07K16/00

Abstract: The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.