公开(公告)号：US11524989B2

公开(公告)日：2022-12-13

申请号：US15737924

申请日：2016-06-24

Applicant: KLING BIOTHERAPEUTICS B.V.

Inventor： Hergen Spits ,  Marijn Aletta Gillissen ,  Martijn Kedde ,  Mette Deborah Hazenberg ,  Paula Maria Wilhelmina van Helden ,  Wouter Pos

IPC: C07K14/435 ,  C07K14/705 ,  C07K16/28 ,  G01N33/574 ,  A61K38/00

Abstract: The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.

公开(公告)号：US11523968B2

公开(公告)日：2022-12-13

申请号：US17210071

申请日：2021-03-23

Applicant: Poolside Tech, LLC

Inventor： William R. Doan ,  Stan Reznik

IPC: G05D11/13 ,  A61H33/00 ,  G05B15/02 ,  E04H4/14 ,  E04H4/12 ,  G05D7/06 ,  G05D11/00 ,  E04H4/16

Abstract: One aspect of the invention provides a computer-implemented method for controlling a swimming pool or spa system. The computer-implemented method includes: creating a data structure representing a plurality of swimming pool system components and fluidic connections between subsets of the plurality of swimming pool system components; receiving a request to control one or more of the plurality of swimming pool system components; calculating fluidic flows through the plurality of swimming pool system components based on one or more potential configurations of the plurality of swimming pool system components capable of fulfilling the request; and detecting whether the one or more potential configurations result in unsatisfactory conditions.

公开(公告)号：US11518754B2

公开(公告)日：2022-12-06

申请号：US16486444

申请日：2018-02-15

Applicant: YALE UNIVERSITY

Inventor： Yiyun Huang ,  Zhengxin Cai ,  Songye Li ,  Nabeel Nabulsi ,  Richard Carson

IPC: C07D401/06 ,  A61K51/04 ,  C07D403/06 ,  A61K9/00

Abstract: In one aspect, the invention comprises compounds that bind to the synaptic vesicle protein SV2A and that can be useful as radiotracers for positron emission tomography. In another aspect, the invention comprises methods of imaging the brain, measuring synaptic density or diagnosing neurological diseases such as Alzheimer's disease, psychiatric disorders such as depression, and metabolic disorders such as diabetes comprising detecting the compounds of the invention by positron emission tomography (PET).

公开(公告)号：US11505551B2

公开(公告)日：2022-11-22

申请号：US17046139

申请日：2019-04-11

Applicant: Arbutus Biopharma Corporation

Inventor： Shuai Chen ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Duyan Nguyen ,  Mahesh Kumar Pallerla ,  Ganapati Reddy Pamulapati

IPC: C07D471/14 ,  C07B49/00 ,  C07B51/00

Abstract: The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.

公开(公告)号：US11504373B2

公开(公告)日：2022-11-22

申请号：US16954514

申请日：2018-12-18

Applicant: YALE UNIVERSITY

Inventor： Anton Bennett ,  Jonathan Ellman ,  Haya Jamali ,  Karen S. Anderson ,  Elias Lolis ,  Denton Hoyer

IPC: A61K31/519 ,  A61K31/517 ,  C07D239/78 ,  C07D471/04 ,  C07D491/052 ,  C07D495/04

Abstract: The present invention provides compounds and methods for treating, ameliorating, and/or preventing a MKP-5 modulated disease. In certain embodiments, the MKP-5 modulated disease is a fibrotic disease.

公开(公告)号：US11497799B2

公开(公告)日：2022-11-15

申请号：US16529174

申请日：2019-08-01

Applicant: YALE UNIVERSITY

Inventor： Dianqing Wu ,  Le Sun

IPC: G01N33/574 ,  A61K39/00 ,  C07K16/18 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28

Abstract: The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor angiogenesis, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of DKK2 gene depleting agent, methods for providing anti-tumor immunity and anti-tumor angiogenesis in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor angiogenesis in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods.

公开(公告)号：US11471496B2

公开(公告)日：2022-10-18

申请号：US16804815

申请日：2020-02-28

Applicant: ROWAN UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Thomas M. Keck ,  Christopher A. Lowry

IPC: A61K35/74 ,  A61P25/30

Abstract: The present invention provides compositions and methods for treating, ameliorating, and/or preventing cocaine addiction in a subject. Immunization by M. vaccae alters serotonin signaling in the brain, reducing stress- and anxiety-like responding in animal models of post-traumatic stress disorder and other anxiety disorders. In certain embodiments, the immunoregulatory, anti-stress, and anxiolytic effects of M. vaccae immunization reduces addiction- and relapse-like responding in models of cocaine addiction and alter the development of cocaine-induced neuroinflammation.

公开(公告)号：US11459295B2

公开(公告)日：2022-10-04

申请号：US15769565

申请日：2016-10-21

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  VANDERBILT UNIVERSITY

Inventor： Trevor M. Penning ,  Adegoke Adeniji ,  Lawrence J. Marnett

IPC: A61K31/405 ,  A61K31/4166 ,  A61K31/506 ,  A61K31/52 ,  A61K31/573 ,  A61K45/06 ,  A61P35/00 ,  C07C57/40 ,  C07C311/51 ,  C07C317/44 ,  C07C323/62 ,  C07C59/64 ,  A61K31/192 ,  A61K31/131 ,  A61K31/16 ,  A61K31/337

Abstract: The invention includes 2-β-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are (R)-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.

公开(公告)号：US11433033B2

公开(公告)日：2022-09-06

申请号：US16936316

申请日：2020-07-22

Applicant: Yale University

Inventor： Gerald I. Shulman ,  Rachel Jamison Perry

IPC: A61K31/06 ,  A61K9/00 ,  A61K9/50 ,  A61K45/06

Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.

公开(公告)号：US11427536B2

公开(公告)日：2022-08-30

申请号：US16019914

申请日：2018-06-27

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Garret Miyake ,  Bin Liu ,  Chern-Hooi Lim

IPC: C07C319/14 ,  C07D213/70 ,  C07D239/38 ,  C07D285/16 ,  C07D235/28 ,  C07D311/54 ,  C07D215/36 ,  C07D277/74 ,  C07D285/22 ,  B01J19/12

Abstract: In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.