Methods and apparatus for time sensitive data transfer between logical domains. In one embodiment, an user equipment (UE) device has an application processor (AP) coupled to a baseband processor (BB) that operate independently of one another normally, but may cooperate in limited hybrid use scenarios. For example, the BB receives audio packets via a cellular network that are converted to pulse code modulated (PCM) digital audio to be played by the AP. Unfortunately, since the AP and the BB are independently clocked, they will experience some clock drift. As a result, the audio playback may have undesirable artifacts if the drift is not otherwise compensated for. To these ends, the AP and/or BB determine a relative clock drift and compensate for playback by e.g., adding, padding, or deleting audio samples and/or audio packets. Techniques for handover scenarios are also disclosed.