Systems, methods, media, and other such embodiments are described for placement of cells in a multi-level routing tree, where placement of a mid-level parent node between a grandparent node and a set of child nodes is not set. One embodiment involves generating a first routing subregion between a first set of child nodes associated with a first grandparent node and a first connecting route from the first routing subregion to the first grandparent node, which together are set as a first routing region comprising the first routing subregion and the first connecting route. Sampling points are selected along the first routing region, and for each sampling point a set of operating values associated with the sampling point is calculated. A position for the parent node is selected based on the operating values for the sampling points.