Detuning and isolation techniques for a multiband tunable matching network used in multi-transceiver RF systems. Embodiments include an amplifier and a multiband tunable matching network (MN) coupled to the amplifier. The multiband tunable MN is configured to detune to an isolation OFF state from an ON state, wherein the match tuning in the isolation OFF state is different than match tuning in the ON state. In an example detuning, the match tuning in the isolation OFF state is in a different frequency band than a frequency band of match tuning in the ON state and is selected based on the frequency band of match tuning in the ON state.