Invention Grant
- Patent Title: Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting
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Application No.: US16310305Application Date: 2017-06-13
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Publication No.: US10604501B2Publication Date: 2020-03-31
- Inventor: Arnaud Chevalier , Omar Khdour , Yanmin Zhang , Sidney Hecht
- Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady LLP
- Agent Jessica L. Lewis
- International Application: PCT/US2017/037253 WO 20170613
- International Announcement: WO2017/218537 WO 20171221
- Main IPC: C07D321/00
- IPC: C07D321/00 ; C07D311/06 ; C07D311/58 ; C07D403/08 ; C07D405/04 ; C07D413/04 ; C07D417/04 ; C07D487/14 ; C07D493/10 ; A61K47/54 ; A61K49/00 ; G01N33/58
Abstract:
The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
Public/Granted literature
- US20190330176A1 PRODRUG AND PROFLUORESCENT COMPOUNDS FOR SELECTIVE MITOCHONDRIAL IMAGING AND THERAPEUTIC TARGETING Public/Granted day:2019-10-31
Information query
