公开(公告)号：US10364227B2

公开(公告)日：2019-07-30

申请号：US15550273

申请日：2016-02-17

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Mohammad Alam ,  Sriloy Dey ,  Yana Chen ,  Arnaud Chevalier

IPC: A61P3/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P35/00 ,  C07D239/47 ,  C07D239/52 ,  C07D401/04 ,  C07D403/04

Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.

公开(公告)号：US10604501B2

公开(公告)日：2020-03-31

申请号：US16310305

申请日：2017-06-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Arnaud Chevalier ,  Omar Khdour ,  Yanmin Zhang ,  Sidney Hecht

IPC: C07D321/00 ,  C07D311/06 ,  C07D311/58 ,  C07D403/08 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/14 ,  C07D493/10 ,  A61K47/54 ,  A61K49/00 ,  G01N33/58

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

公开(公告)号：US11203583B2

公开(公告)日：2021-12-21

申请号：US16784202

申请日：2020-02-06

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Arnaud Chevalier ,  Omar Khdour ,  Yanmin Zhang ,  Sidney Hecht

IPC: C07D321/00 ,  C07D311/06 ,  C07D311/58 ,  C07D403/08 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/14 ,  C07D493/10 ,  A61K47/54 ,  A61K49/00 ,  G01N33/58

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.