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公开(公告)号：US10745366B2
公开(公告)日：2020-08-18
申请号：US16327284
申请日：2017-08-24
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Nishant P Visavadiya
IPC: C07D279/18 , A61K31/5415 , A61P39/06 , C07D279/14 , A61P25/28 , A61P9/00 , A61P3/10 , A61P35/00
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10364227B2
公开(公告)日：2019-07-30
申请号：US15550273
申请日：2016-02-17
Inventor： Sidney Hecht , Omar Khdour , Mohammad Alam , Sriloy Dey , Yana Chen , Arnaud Chevalier
IPC: A61P3/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00 , C07D239/47 , C07D239/52 , C07D401/04 , C07D403/04
Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.
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公开(公告)号：US11034662B2
公开(公告)日：2021-06-15
申请号：US16659308
申请日：2019-10-21
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Indrajit Bandyopadhyay
IPC: C07D279/18 , C07D279/20 , C07D417/04 , C07D417/14
Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1, R2, R3, R6 and Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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Patent Agency Ranking
4.发明授权公开(公告)号：US10604501B2
公开(公告)日：2020-03-31
申请号：US16310305
申请日：2017-06-13
Inventor： Arnaud Chevalier , Omar Khdour , Yanmin Zhang , Sidney Hecht
IPC: C07D321/00 , C07D311/06 , C07D311/58 , C07D403/08 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/14 , C07D493/10 , A61K47/54 , A61K49/00 , G01N33/58
Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
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5.发明授权公开(公告)号：US11203583B2
公开(公告)日：2021-12-21
申请号：US16784202
申请日：2020-02-06
Inventor： Arnaud Chevalier , Omar Khdour , Yanmin Zhang , Sidney Hecht
IPC: C07D321/00 , C07D311/06 , C07D311/58 , C07D403/08 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/14 , C07D493/10 , A61K47/54 , A61K49/00 , G01N33/58
Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
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公开(公告)号：US10472340B2
公开(公告)日：2019-11-12
申请号：US15550282
申请日：2016-02-17
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Indrajit Bandyopadhyay
IPC: A61K31/5415 , C07D279/18 , C07D279/20 , C07D417/04 , C07D417/14
Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：US11560360B2
公开(公告)日：2023-01-24
申请号：US16924763
申请日：2020-07-09
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Nishant P. Visavadiya
IPC: C07D279/18 , C07D279/14 , A61P39/06 , A61P35/00 , A61P3/10 , A61P9/00 , A61P25/28 , A61K31/5415
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US09957214B2
公开(公告)日：2018-05-01
申请号：US14434725
申请日：2013-10-10
Inventor： Manikandadas Mathilakathu Madathil , Omar Khdour , Sidney Hecht
IPC: C07C46/02 , C07C49/753 , C07C225/06 , C07C225/20 , C07D225/06 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48 , C07C229/10
CPC classification number: C07C49/753 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07C46/02 , C07C225/20 , C07C229/10 , C07D225/06 , C07C50/28
Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
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