公开(公告)号：US20220362375A1

公开(公告)日：2022-11-17

申请号：US17743058

申请日：2022-05-12

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Yung Chang ,  Sidney Hecht ,  Joseph Leal ,  Viswanath Arutla ,  Xiaowei Liu ,  Sriram Sokalingam

IPC: A61K39/385 ,  C07D401/14 ,  G16B15/00 ,  G16B20/00 ,  A61K47/64 ,  G01N33/94 ,  A61K39/00 ,  G16B15/30 ,  G16B20/30

Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.

公开(公告)号：US10745366B2

公开(公告)日：2020-08-18

申请号：US16327284

申请日：2017-08-24

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Sandipan Roy Chowdhury ,  Nishant P Visavadiya

IPC: C07D279/18 ,  A61K31/5415 ,  A61P39/06 ,  C07D279/14 ,  A61P25/28 ,  A61P9/00 ,  A61P3/10 ,  A61P35/00

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US10364227B2

公开(公告)日：2019-07-30

申请号：US15550273

申请日：2016-02-17

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Mohammad Alam ,  Sriloy Dey ,  Yana Chen ,  Arnaud Chevalier

IPC: A61P3/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P35/00 ,  C07D239/47 ,  C07D239/52 ,  C07D401/04 ,  C07D403/04

Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.

公开(公告)号：US20160375131A1

公开(公告)日：2016-12-29

申请号：US15189930

申请日：2016-06-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Yung Chang ,  Sidney Hecht ,  Joseph Leal ,  Viswanath Arutla ,  Xiaowei Liu ,  Sriram Sokalingam ,  Paul Pentel

IPC: A61K39/385 ,  G01N33/94 ,  G06F19/16 ,  G06F19/18 ,  C07D401/14 ,  A61K47/48

CPC classification number: A61K39/385 ,  A61K39/0013 ,  A61K47/646 ,  A61K2039/6012 ,  C07D401/14 ,  G01N33/946 ,  G06F19/16 ,  G06F19/18

Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.

Abstract translation: 本文提供了尼古丁半抗原合理设计的方法。 更具体地，本文提供了用于设计，选择和合成尼古丁半抗原和尼古丁半抗原共轭物的方法。 本文还提供了新型尼古丁半抗原以及使用尼古丁半抗原来治疗尼古丁成瘾的方法。

公开(公告)号：US11560360B2

公开(公告)日：2023-01-24

申请号：US16924763

申请日：2020-07-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Sandipan Roy Chowdhury ,  Nishant P. Visavadiya

IPC: C07D279/18 ,  C07D279/14 ,  A61P39/06 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/28 ,  A61K31/5415

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US09957214B2

公开(公告)日：2018-05-01

申请号：US14434725

申请日：2013-10-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Manikandadas Mathilakathu Madathil ,  Omar Khdour ,  Sidney Hecht

IPC: C07C46/02 ,  C07C49/753 ,  C07C225/06 ,  C07C225/20 ,  C07D225/06 ,  A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  C07C229/10

CPC classification number: C07C49/753 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/08 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  C07C46/02 ,  C07C225/20 ,  C07C229/10 ,  C07D225/06 ,  C07C50/28

Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.

公开(公告)号：US11357848B2

公开(公告)日：2022-06-14

申请号：US15863118

申请日：2018-01-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Yung Chang ,  Sidney Hecht ,  Joseph Leal ,  Viswanath Arutla ,  Xiaowei Liu ,  Sriram Sokalingam

IPC: A61K39/385 ,  C07D401/14 ,  G16B15/00 ,  G16B20/00 ,  A61K47/64 ,  G01N33/94 ,  A61K39/00 ,  G16B15/30 ,  G16B20/30

Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.

公开(公告)号：US11034662B2

公开(公告)日：2021-06-15

申请号：US16659308

申请日：2019-10-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Sandipan Roy Chowdhury ,  Indrajit Bandyopadhyay

IPC: C07D279/18 ,  C07D279/20 ,  C07D417/04 ,  C07D417/14

Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1, R2, R3, R6 and Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

公开(公告)号：US10604501B2

公开(公告)日：2020-03-31

申请号：US16310305

申请日：2017-06-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Arnaud Chevalier ,  Omar Khdour ,  Yanmin Zhang ,  Sidney Hecht

IPC: C07D321/00 ,  C07D311/06 ,  C07D311/58 ,  C07D403/08 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/14 ,  C07D493/10 ,  A61K47/54 ,  A61K49/00 ,  G01N33/58

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

公开(公告)号：US20180125969A1

公开(公告)日：2018-05-10

申请号：US15863118

申请日：2018-01-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Yung Chang ,  Sidney Hecht ,  Joseph Leal ,  Viswanath Arutla ,  Xiaowei Liu ,  Sriram Sokalingam

IPC: A61K39/385 ,  C07D401/14 ,  G06F19/16 ,  G06F19/18 ,  A61K47/64

CPC classification number: A61K39/385 ,  A61K39/0013 ,  A61K47/646 ,  A61K2039/6012 ,  C07D401/14 ,  G01N33/946 ,  G16B15/00 ,  G16B20/00

Abstract: Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.