Invention Grant
- Patent Title: Direct reprogramming of cells to cardiac myocyte fate
-
Application No.: US15997422Application Date: 2018-06-04
-
Publication No.: US10695378B2Publication Date: 2020-06-30
- Inventor: Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ingrid A. Beattie
- Main IPC: A61K35/33
- IPC: A61K35/33 ; A61L27/38 ; A61L27/54 ; A61L29/16 ; A61L31/16 ; C12N15/113 ; C12N5/077
Abstract:
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
Public/Granted literature
- US20180344776A1 Direct Reprogramming of Cells to Cardiac Myocyte Fate Public/Granted day:2018-12-06
Information query
