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公开(公告)号：US10695378B2
公开(公告)日：2020-06-30
申请号：US15997422
申请日：2018-06-04
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US11534464B2
公开(公告)日：2022-12-27
申请号：US16915225
申请日：2020-06-29
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US20200345786A1
公开(公告)日：2020-11-05
申请号：US16915225
申请日：2020-06-29
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US20180344776A1
公开(公告)日：2018-12-06
申请号：US15997422
申请日：2018-06-04
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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