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公开(公告)号：US10130637B2
公开(公告)日：2018-11-20
申请号：US14440567
申请日：2013-11-04
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou
IPC: A61K31/551 , A61K31/437 , A61K45/06 , C07D487/04 , C07D401/14 , C12N15/113 , A61K35/34
Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
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公开(公告)号：US11534464B2
公开(公告)日：2022-12-27
申请号：US16915225
申请日：2020-06-29
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US20200345786A1
公开(公告)日：2020-11-05
申请号：US16915225
申请日：2020-06-29
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US20180344776A1
公开(公告)日：2018-12-06
申请号：US15997422
申请日：2018-06-04
Applicant: Duke University
Inventor： Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
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公开(公告)号：US20140357703A1
公开(公告)日：2014-12-04
申请号：US14256169
申请日：2014-04-18
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , Duke University
Inventor： Victor J. Dzau , Maria Mirotsou
IPC: C07K14/475 , C07K14/435
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K38/17 , A61K38/18 , A61K45/06 , C07K14/435 , C07K14/475 , C12N5/10 , C12N15/09 , C12N15/63
Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
Abstract translation: 间充质干细胞（如分泌型卷曲相关蛋白（Sfrp））的纯化旁分泌因子可用于减少与缺血性疾病相关的细胞死亡或组织损伤。
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Patent Agency Ranking
公开(公告)号：US12285444B2
公开(公告)日：2025-04-29
申请号：US17541917
申请日：2021-12-03
Applicant: Duke University
Inventor： Conrad P. Hodgkinson , Victor J. Dzau
IPC: A61K35/33 , C12N5/077 , C12N15/113
Abstract: The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.
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7.发明授权Method of reducing cell death by administering a paracrine factor derived from a mesenchymal stem cell 有权通过施用源自间充质干细胞的旁分泌因子来减少细胞死亡的方法公开(公告)号：US09353168B2
公开(公告)日：2016-05-31
申请号：US14256174
申请日：2014-04-18
Applicant: The Brigham and Women's Hospital, Inc. , Duke University
Inventor： Victor J. Dzau , Maria Mirotsou
IPC: A61K38/17 , C07K14/435 , C07K14/475 , A61K38/18 , C12N15/09 , C12N15/63 , C12N5/10
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K38/17 , A61K38/18 , A61K45/06 , C07K14/435 , C07K14/475 , C12N5/10 , C12N15/09 , C12N15/63
Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.
Abstract translation: 间充质干细胞如分泌型卷曲相关蛋白（Sfrp）的纯化旁分泌因子可用于减少与缺血状况相关的细胞死亡和/或组织损伤。
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8.发明授权Method of reducing cell death by administering a nucleic acid encoding a paracrine factor of a mesenchymal stem cell 有权通过施用编码间充质干细胞的旁分泌因子的核酸来减少细胞死亡的方法公开(公告)号：US09279012B2
公开(公告)日：2016-03-08
申请号：US14256169
申请日：2014-04-18
Applicant: The Brigham and Women's Hospital, Inc. , Duke University
Inventor： Victor J. Dzau , Maria Mirotsou
IPC: A61K38/17 , C07K14/435 , C07K14/475 , C12N15/09 , C12N15/63 , A61K38/18 , C12N5/10
CPC classification number: A61K38/1709 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K38/17 , A61K38/18 , A61K45/06 , C07K14/435 , C07K14/475 , C12N5/10 , C12N15/09 , C12N15/63
Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
Abstract translation: 间充质干细胞（如分泌型卷曲相关蛋白（Sfrp））的纯化旁分泌因子可用于减少与缺血性疾病相关的细胞死亡或组织损伤。
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公开(公告)号：US20240197640A1
公开(公告)日：2024-06-20
申请号：US18474697
申请日：2023-09-26
Applicant: Duke University
Inventor： Conrad P. Hodgkinson , Hualing Sun , Victor J. Dzau
IPC: A61K9/50 , A61P9/00 , C12N5/071 , C12N15/113
CPC classification number: A61K9/5068 , A61P9/00 , C12N5/069 , C12N15/113 , C12N2310/141
Abstract: The present disclosure describes, in part, exosomes comprising miRNA for the reprogramming of fibroblasts and methods of using the same.
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公开(公告)号：US20150297611A1
公开(公告)日：2015-10-22
申请号：US14440567
申请日：2013-11-04
Applicant: DUKE UNIVERSITY
Inventor： Victor J. Dzau , Maria Mirotsou
IPC: A61K31/551 , C07D401/14 , C07D487/04 , A61K31/437 , A61K45/06
CPC classification number: A61K31/551 , A61K31/437 , A61K35/34 , A61K45/06 , A61P9/00 , A61P9/10 , A61P9/12 , C07D401/14 , C07D487/04 , C12N15/1137 , C12N2310/141 , C12N2320/30 , C12Y201/01043 , C12Y201/01125 , C12Y207/10002 , C12Y207/11001
Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
Abstract translation: 通过使非心肌细胞或组织与组蛋白甲基转移酶活性或表达的调节剂接触来促进非心肌细胞或组织的重编程的方法，所述心肌细胞或组织被重组为心肌细胞或组织。
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