- 专利标题： Selective oxidation of 5-methylcytosine by TET-family proteins
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申请号： US15725917申请日： 2017-10-05
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公开(公告)号： US10731204B2公开(公告)日： 2020-08-04
- 发明人: Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
- 申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
- 申请人地址： US MA Boston US MD Bethesda
- 专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： CHILDREN'S MEDICAL CENTER CORPORATION,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： US MA Boston US MD Bethesda
- 代理机构： Nixon Peabody LLP
- 主分类号： C12Q1/6827
- IPC分类号： C12Q1/6827 ; C12Q1/26 ; C12Q1/6806 ; C12Q1/6869 ; G01N33/53
摘要：
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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