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公开(公告)号：US20240318235A1
公开(公告)日：2024-09-26
申请号：US18739955
申请日：2024-06-11
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20210246494A1
公开(公告)日：2021-08-12
申请号：US17231671
申请日：2021-04-15
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , G01N33/53 , C12Q1/6806 , C12Q1/6869
摘要： The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base.
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公开(公告)号：US20200040381A1
公开(公告)日：2020-02-06
申请号：US16658195
申请日：2019-10-21
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , G01N33/50 , C12N9/02 , G01N33/53 , C12N5/00 , C12Q1/6806 , C12N5/074 , G01N33/574 , C12N5/0783 , C12N15/873 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US10465234B2
公开(公告)日：2019-11-05
申请号：US16169801
申请日：2018-10-24
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/26 , C12Q1/6827 , G01N33/50 , C12N9/02 , G01N33/53 , C12N5/00 , C12Q1/6806 , C12N5/074 , G01N33/574 , C12N5/0783 , C12N15/873 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US10031131B2
公开(公告)日：2018-07-24
申请号：US15440284
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/574 , G01N33/53 , C12N5/074
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20240254542A1
公开(公告)日：2024-08-01
申请号：US18588987
申请日：2024-02-27
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TEM3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20240254541A1
公开(公告)日：2024-08-01
申请号：US18588930
申请日：2024-02-27
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20220348995A1
公开(公告)日：2022-11-03
申请号：US17675502
申请日：2022-02-18
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/6869 , C12Q1/26 , G01N33/53 , C12N9/10 , C12Q1/6806
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US11072818B2
公开(公告)日：2021-07-27
申请号：US16380846
申请日：2019-04-10
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/26 , C12Q1/6827 , G01N33/53 , C12Q1/6806 , C12Q1/6869
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US10731204B2
公开(公告)日：2020-08-04
申请号：US15725917
申请日：2017-10-05
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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