- 专利标题: Abuse resistant oral opioid formulations
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申请号: US12680701申请日: 2008-08-12
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公开(公告)号: US10736850B2公开(公告)日: 2020-08-11
- 发明人: Manish S. Shah , Ray Difalco
- 申请人: Manish S. Shah , Ray Difalco
- 申请人地址: US PR Juncos
- 专利权人: OHEMO Life Sciences Inc.
- 当前专利权人: OHEMO Life Sciences Inc.
- 当前专利权人地址: US PR Juncos
- 代理机构: Arent Fox LLP
- 国际申请: PCT/US2008/072914 WO 20080812
- 国际公布: WO2009/023672 WO 20090219
- 主分类号: A61K9/24
- IPC分类号: A61K9/24 ; A61K9/28 ; A61K9/32 ; A61K9/20 ; A61K31/138 ; A61K31/437 ; A61K31/4458 ; A61K9/48 ; A61K31/485 ; A61K9/16 ; A61K9/50 ; A61K47/32 ; A61K47/34 ; A61K47/38
摘要:
An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
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