公开(公告)号：US11045422B2

公开(公告)日：2021-06-29

申请号：US13040953

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US20110159089A1

公开(公告)日：2011-06-30

申请号：US13041024

申请日：2011-03-04

申请人： Manish S. SHAH ,  Ray Difalco

发明人： Manish S. SHAH ,  Ray Difalco

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61K9/24 ,  A61K9/52 ,  A61K9/14 ,  A61P29/00 ,  A61P25/04 ,  B05D1/02 ,  B05D1/00 ,  B05D1/36 ,  B05D5/00

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (G1) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

摘要翻译： 一种抗滥用口服药物组合物，其包含：阻挡层，包含第一聚合物; 扩散层，其包括基本上覆盖所述阻挡层的第二聚合物，其中所述扩散层与所述阻挡层结合并且包含基本上均匀分布在所述第二聚合物内并从所述胃肠道（G1）内的扩散层扩散的药物， 道; 和任选的包含可膨胀聚合物的膨胀层，其中膨胀层基本上被阻挡层覆盖。 还提供了制备方法和使用方法。

公开(公告)号：US10695298B2

公开(公告)日：2020-06-30

申请号：US13040701

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10688052B2

公开(公告)日：2020-06-23

申请号：US13040792

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US20120164209A1

公开(公告)日：2012-06-28

申请号：US13408076

申请日：2012-02-29

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/00 ,  A61K9/32 ,  A61K9/48 ,  A61K9/14 ,  A61K9/16 ,  A61K31/485 ,  A61K31/4458 ,  A61K31/519 ,  A61K31/138 ,  A61K31/137 ,  A61P29/00 ,  A61P25/26 ,  A61P25/00 ,  A61P25/04 ,  B05D3/10 ,  A61K31/167

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10736851B2

公开(公告)日：2020-08-11

申请号：US13041020

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US20110150991A1

公开(公告)日：2011-06-23

申请号：US13041020

申请日：2011-03-04

申请人： Manish S. SHAH ,  Ray Difalco

发明人： Manish S. SHAH ,  Ray Difalco

IPC分类号： A61K9/52 ,  A61K9/00 ,  A61K31/485 ,  A61K9/24 ,  A61P29/00 ,  A61P25/30 ,  A61P25/04 ,  B05D1/02 ,  B05D1/00 ,  B05D1/36 ,  B05D5/00

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US20110150970A1

公开(公告)日：2011-06-23

申请号：US13040775

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/00 ,  A61K9/48 ,  A61K9/32 ,  A61K9/50 ,  A61K31/34 ,  B05D1/02 ,  B05D1/00 ,  B05D1/36 ,  B05D5/00

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10736850B2

公开(公告)日：2020-08-11

申请号：US12680701

申请日：2008-08-12

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10688053B2

公开(公告)日：2020-06-23

申请号：US13040979

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.