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    ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING
    3.
    发明申请
    ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING 审中-公开

    公开(公告)号：US20110150971A1

    公开(公告)日：2011-06-23

    申请号：US13040792

    申请日：2011-03-04

    申请人： Manish S. SHAH ,  Ray DIFALCO

    发明人： Manish S. SHAH ,  Ray DIFALCO

    IPC分类号： A61K9/00 ,  A61K9/48 ,  A61K9/32 ,  A61K9/50 ,  A61K31/34 ,  B05D1/02 ,  B05D1/00 ,  B05D1/36 ,  B05D5/00

    摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

    Pharmaceutical compositions configured to deter dosage form splitting
    7.
    发明授权
    Pharmaceutical compositions configured to deter dosage form splitting 有权

    公开(公告)号：US10314788B2

    公开(公告)日：2019-06-11

    申请号：US13058757

    申请日：2009-02-12

    申请人： Manish S. Shah ,  Ray J. Difalco

    发明人： Manish S. Shah ,  Ray J. Difalco

    IPC分类号： A61K31/485 ,  A61P25/04 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458

    摘要： An oral pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in a monolithic dosage form, wherein the dosage form is configured such that when the dosage form is divided into more than one piece and at least one of the pieces is administered to a subject the Cmax, AUC, and/or rate of drug released after administration is substantially the same or lower and the Tmax is higher than the Cmax, AUC, rate of drug released, and/or Tmax after administration of: (1) a comparable composition in intact dosage form of equal drug dosage of the administered at least one piece; (2) a bioequivalent drug composition in an intact dosage form of equal drug dosage to the administered at least one piece; and (3) a divided piece of a bioequivalent drug composition, wherein the divided piece comprises a drug dosage equal to the dosage of the administered piece of the oral composition. Methods of making the same and methods of using the same are also provided.

    ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING
    9.
    发明申请
    ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING 审中-公开

    公开(公告)号：US20110150970A1

    公开(公告)日：2011-06-23

    申请号：US13040775

    申请日：2011-03-04

    申请人： Manish S. Shah ,  Ray Difalco

    发明人： Manish S. Shah ,  Ray Difalco

    IPC分类号： A61K9/00 ,  A61K9/48 ,  A61K9/32 ,  A61K9/50 ,  A61K31/34 ,  B05D1/02 ,  B05D1/00 ,  B05D1/36 ,  B05D5/00

    摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.