发明授权
- 专利标题： Neutralising antibodies to the major exotoxins TCDA and TCDB of Clostridium difficile
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申请号： US14344637申请日： 2012-09-10
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公开(公告)号： US10752676B2公开(公告)日： 2020-08-25
- 发明人: David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon Mackenzie , Matthew Cox
- 申请人： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon Mackenzie , Matthew Cox
- 申请人地址： BE Brussels
- 专利权人： UCB Biopharma SPRL
- 当前专利权人： UCB Biopharma SPRL
- 当前专利权人地址： BE Brussels
- 代理机构： Saul Ewing Arnstein & Lehr LLP
- 代理商 Doreen Y. Trujillo
- 国际申请： PCT/GB2012/052222 WO 20120910
- 国际公布： WO2013/038156 WO 20130321
- 主分类号： C07K16/12
- IPC分类号： C07K16/12 ; A61K39/40 ; A61K45/06 ; A61K39/00 ; G01N33/569 ; G01N33/573 ; G01N33/68
摘要：
This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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