摘要:
This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
摘要:
Compounds are disclosed that have formula I: where A, B, L1, W, Y, R1, and R3 are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, anxiety, depression, inflammation, cognitive disorders, weight and eating disorders, Parkinson's disease, Alzheimer's disease, spasticity, addiction, glaucoma, and others.
摘要:
Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要:
Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要:
Embodiments of a power miter saw of the type which has an upper fixed blade guard and a lower swinging blade guard for covering the lower reach of an installed blade when the saw is in its rest position and for exposing the lower reach of the saw blade when moved to its operational position, the saw comprising an elongated linkage mechanism interconnecting a frame support and the lower blade guard for moving the lower blade guard in response to movement of the saw between the rest and operational positions, such that the lower blade guard covers the lower reach of the blade when the saw is in its rest position and uncovers the blade when the saw is moved to its operational position, the linkage mechanism being configured to have an adjustable length and be placed in at least first and second positions wherein the first position enables normal movement of the saw between its rest and operational positions, and the second position wherein the lower blade guard is raised to expose a blade arbor to facilitate changing of the blade.
摘要:
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要:
A power miter saw of the type which has an upper fixed blade guard and a lower swinging blade guard for covering the lower reach of an installed blade when the saw is in its rest position and for exposing the lower reach of the saw blade when moved to its operational position, the saw comprising an adjustable length elongated linkage mechanism interconnecting a frame support and the lower blade guard for moving the lower blade guard in response to movement of the saw between the rest and operational positions, such that the lower blade guard covers the lower reach of the blade when the saw is in its rest position and uncovers the blade when the saw is moved to its operational position, the linkage mechanism permitting the exposure of a blade arbor to facilitate changing of the blade.
摘要:
Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要:
A miter saw with work surface extensions comprises a base with a rotatable table positioned on the base. The miter saw further comprises a bevel support is that is pivotable with respect to a table surface. A cutting blade is supported by the bevel support. A work surface extension is moveably connected to the base between a retracted position and an extended position. The work surface extension provides a work surface that is substantially planar with the table surface. At least one elongated member is fixed to the work surface extension and moveably engages the base. A substantial portion of the at least one elongated member is positioned within or under the base when the work surface extension is in the retracted position. The substantial portion of the at least one elongated member is positioned between the base and the work surface extension when the at least one elongated member is in the extended position.