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    MULTIVALENT ANTIBODIES
    5.
    发明申请
    MULTIVALENT ANTIBODIES 审中-公开
    多功能抗体

    公开(公告)号：US20130066054A1

    公开(公告)日：2013-03-14

    申请号：US13510165

    申请日：2010-11-17

    申请人： David Paul Humphreys ,  Sam Philip Heywood ,  Alastair David Griffiths Lawson

    发明人： David Paul Humphreys ,  Sam Philip Heywood ,  Alastair David Griffiths Lawson

    IPC分类号： C07K16/00

    CPC分类号： C07K16/00 ,  A61K47/60 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/624

    摘要： A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.

    摘要翻译： 一种多价抗体融合蛋白，其包含：重链，其从N末端依次包含名义上为VH1的可变区，CH1区和名义上为VH2的另外的可变区，轻链，其从N末端依次包含， 可变结构域名义上为VL1，CL结构域和名义上为VL2的可变结构域，其中所述重链和轻链对齐以提供由第一可变结构域对VH1和VL1形成的第一结合位点和由第二结合位点形成的第二结合位点 VH2和VL2的可变结构域对，其中在形成结合位点的可变结构域对之间存在二硫键，并且所述融合蛋白与PEG聚合物缀合。

    Modified Antibody Fragments
    6.
    发明申请
    Modified Antibody Fragments 有权
    修饰抗体片段

    公开(公告)号：US20080269466A1

    公开(公告)日：2008-10-30

    申请号：US11995740

    申请日：2006-07-17

    申请人： David Paul Humphreys

    发明人： David Paul Humphreys

    IPC分类号： C07K16/18 ,  C07K1/00

    CPC分类号： C07K16/00 ,  A61K47/60 ,  A61K47/6889 ,  C07K2317/55 ,  C07K2317/624

    摘要： The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.

    摘要翻译： 本发明涉及一类新的修饰的抗体片段。 本发明提供了一种或多种效应分子附着的抗体片段，其特征在于重（CHI）和轻链（CL）链恒定区之间的天然链间二硫键不存在，重链（CHI）和轻链 （CL）恒定区通过一对工程化半胱氨酸之间的链间二硫键连接，一个在轻链常数（CL）区域中，另一个在重链恒定（CHI）区域中。

    DISULFIDE STABILIZED DVD-LG MOLECULES
    7.
    发明申请
    DISULFIDE STABILIZED DVD-LG MOLECULES 审中-公开
    DISLIFITE稳定的DVD-LG分子

    公开(公告)号：US20160244532A2

    公开(公告)日：2016-08-25

    申请号：US13637211

    申请日：2011-03-25

    申请人： Sam Philip Heywood ,  David Paul Humphreys

    发明人： Sam Philip Heywood ,  David Paul Humphreys

    IPC分类号： C07K16/46

    摘要： The present disclosure provides a binding protein comprising: a polypeptide heavy chain comprising: VH1—(X1)n-VH2—CH (X2)y wherein VH1 is a first variable domain, VH2 is a second variable domain, CH is a constant domain, X1 represents an amino acid or peptide, X2 represents an Fc region, n is 0 or 1 and y is independently 1 or 2, and a polypeptide light chain comprising: VL1-(X1)n-VL2-C wherein VL1 is a first variable domain, VL2 is a second variable domain, C is a constant domain, X1 represents an amino acid or peptide and n is 0 or 1, wherein the heavy chain and light chain are aligned such that VH1 and VL1 form a first binding domain, and VH2 and VL2 form a second binding domain and wherein: there is a disulfide bond between VH1 and VL1, and/or there is a disulfide bond between VH2 and VL2, and use thereof in treatment.

    摘要翻译： 本发明提供了一种结合蛋白，其包含：多肽重链，其包含：VH1-（X1）n-VH2-CH（X2）y，其中VH1是第一可变结构域，VH2是第二可变结构域，CH是恒定结构域， X1表示氨基酸或肽，X2表示Fc区，n表示0或1，y独立地为1或2，多肽轻链包含：VL1-（X1）n-VL2-C，其中VL1为第一个变量 结构域，VL2是第二可变结构域，C是恒定结构域，X1表示氨基酸或肽，n是0或1，其中重链和轻链排列使得VH1和VL1形成第一结合结构域，以及 VH2和VL2形成第二结合结构域，其中：VH1和VL1之间存在二硫键，和/或在VH2和VL2之间存在二硫键，以及其在治疗中的用途。

    Disulfide stabilized antibodies and fragments thereof
    8.
    发明授权
    Disulfide stabilized antibodies and fragments thereof 有权
    二硫键稳定的抗体及其片段

    公开(公告)号：US09045529B2

    公开(公告)日：2015-06-02

    申请号：US13637209

    申请日：2011-03-25

    申请人： David Paul Humphreys

    发明人： David Paul Humphreys

    IPC分类号： A61K38/00 ,  C07K16/00

    CPC分类号： C07K16/00 ,  C07K2317/55 ,  C07K2317/94

    摘要： The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.

    摘要翻译： 本公开内容提供了包含至少一个Fab分子的抗体或抗体片段，其中Fab分子的轻链可变区VL和重链区域VH通过一个或多个二硫键连接，并且使用它们 治疗或预防。

    Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity
    9.
    发明授权
    Bacterial host strain comprising a mutant SPR gene and having reduced TSP activity 有权
    包含突变体SPR基因并具有降低的TSP活性的细菌宿主菌株

    公开(公告)号：US08969039B2

    公开(公告)日：2015-03-03

    申请号：US13522087

    申请日：2011-01-13

    申请人： Mark Ellis ,  David Paul Humphreys

    发明人： Mark Ellis ,  David Paul Humphreys

    IPC分类号： C12N15/70 ,  C12N15/09 ,  C07K14/245 ,  C12N9/52

    CPC分类号： C12N9/0006 ,  C07K14/245 ,  C12N9/52 ,  C12N15/70 ,  C12Y101/01

    摘要： The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.

    摘要翻译： 本发明提供了一种重组革兰氏阴性细菌细胞，其包含编码具有在一个或多个选自D133，H145，H157，N31，R62，I70，Q73，C94，S95，V98的氨基酸的突变的spr蛋白的突变型spr基因 ，Q99，R100，L108，Y115，V135，L136，G140，R144和G147，并且其中与野生型细胞相比，细胞具有降低的Tsp蛋白活性。

    Multivalent Antibodies
    10.
    发明申请
    Multivalent Antibodies 审中-公开
    多价抗体

    公开(公告)号：US20120283415A1

    公开(公告)日：2012-11-08

    申请号：US13395235

    申请日：2010-09-10

    申请人： David Paul Humphreys ,  Emma Dave ,  Ralph Adams

    发明人： David Paul Humphreys ,  Emma Dave ,  Ralph Adams

    IPC分类号： C07K16/00

    摘要： The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    摘要翻译： 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。