Invention Grant
- Patent Title: Frequency-based modulation of diverse species in a nucleic acid library
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Application No.: US16310643Application Date: 2017-06-21
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Publication No.: US10851369B2Publication Date: 2020-12-01
- Inventor: Reza Kalhor , Javier Fernandez Juarez , Henry Hung-yi Lee , George M. Church
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2017/038414 WO 20170621
- International Announcement: WO2017/223127 WO 20171228
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/10 ; C12N15/11 ; C40B40/02 ; C40B50/06 ; C12N15/09 ; C12N9/22
Abstract:
A method of processing a collection of nucleic acid sequences is provided including connecting an adaptor to one or more or each nucleic acid sequence in the collection to create a processed nucleic acid template library, wherein the adaptor includes a first DNA sequence encoding a PAM sequence and at least a tracr mate.
Public/Granted literature
- US20190177720A1 Frequency-Based Modulation of Diverse Species in a Nucleic Acid Library Public/Granted day:2019-06-13
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