- 专利标题： Methods and devices to detect the presence of a condition associated with ATP depletion in a subject
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申请号： US15580582申请日： 2016-06-03
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公开(公告)号： US10889846B2公开(公告)日： 2021-01-12
- 发明人: Nicholas Dale , Chris Imray , Bruno Frenguelli
- 申请人： Sarissa Biomedical Limited
- 申请人地址： GB Coventry
- 专利权人： Sarissa Biomedical Limited
- 当前专利权人： Sarissa Biomedical Limited
- 当前专利权人地址： GB Coventry
- 代理机构： Brannon Sowers & Cracraft PC
- 优先权： GB1509974.0 20150609
- 国际申请： PCT/GB2016/051641 WO 20160603
- 国际公布： WO2016/198839 WO 20161215
- 主分类号： G01N27/327
- IPC分类号： G01N27/327 ; C12Q1/00 ; G01N33/53 ; G01N33/543 ; C12Q1/26 ; C12Q1/34 ; C12Q1/48
摘要：
The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.
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