公开(公告)号：US10889846B2

公开(公告)日：2021-01-12

申请号：US15580582

申请日：2016-06-03

申请人： Sarissa Biomedical Limited

发明人： Nicholas Dale ,  Chris Imray ,  Bruno Frenguelli

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/543 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48

摘要： The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.

公开(公告)号：US20180155754A1

公开(公告)日：2018-06-07

申请号：US15580582

申请日：2016-06-03

申请人： Sarissa Biomedical Limited

发明人： Nicholas Dale ,  Chris Imray ,  Bruno Frenguelli

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/48 ,  C12Q1/34 ,  G01N27/327

CPC分类号： C12Q1/005 ,  C12Q1/004 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  C12Y117/03002 ,  C12Y204/02001 ,  C12Y305/04004 ,  G01N27/3271 ,  G01N33/5308 ,  G01N33/5438 ,  G01N2800/7019

摘要： The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.