Methods and compositions for recombinase-based genetic diversification

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US10961513B2 Methods and compositions for recombinase-based genetic diversification 有权

Patent Title: Methods and compositions for recombinase-based genetic diversification
Application No.: US15757530

Application Date: 2016-09-07
Publication No.: US10961513B2

Publication Date: 2021-03-30
Inventor: Timothy Kuan-Ta Lu , Sara da Luz Areosa Cleto
Applicant: Massachusetts Institute of Technology
Applicant Address: US MA Cambridge
Assignee: Massachusetts Institute of Technology
Current Assignee: Massachusetts Institute of Technology
Current Assignee Address: US MA Cambridge
Agency: Wolf, Greenfield & Sacks, P.C.
International Application: PCT/US2016/050533 WO 20160907
International Announcement: WO2017/044476 WO 20170316
Main IPC: C12N9/00
IPC: C12N9/00 ; C12N15/00 ; C12N15/82 ; C07H21/04 ; C12N15/52 ; C12N9/24 ; C12N15/70 ; C12N15/74

Abstract:

Compositions and methods using shufflon recombinases are presented for use in generating genetic diversity in molecules of interest.

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IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N9/00	酶，如连接酶（6.）；酶原；其组合物（用于清洁牙齿的含酶的制剂入A61K8/66、A61Q11/00；含酶或酶原的医药制剂入A61K38/43；含酶去污剂组合物入C11D）；制备、活化、抑制、分离或纯化酶的方法