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公开(公告)号：US11026419B2
公开(公告)日：2021-06-08
申请号：US16349800
申请日：2017-11-20
Applicant: Massachusetts Institute of Technology
Inventor： T. Alan Hatton , Timothy Kuan-Ta Lu , Paul Brown , Cesar de la Fuente Nunez , Sahag Voskian
Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.
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公开(公告)号：US20190225674A1
公开(公告)日：2019-07-25
申请号：US16316980
申请日：2017-07-11
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu
Abstract: Described herein are methods and compositions for the rapid production of therapeutic molecules using an inducible cell culture system.
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公开(公告)号：US09957511B2
公开(公告)日：2018-05-01
申请号：US14320965
申请日：2014-07-01
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , James Collins , Russell-John Krom
CPC classification number: C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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4.发明申请公开(公告)号：US20170360850A1
公开(公告)日：2017-12-21
申请号：US15535831
申请日：2015-12-22
Applicant: Massachusetts Institute of Technology , Synlogic, Inc.
Inventor： Timothy Kuan-Ta Lu , Jacob Rosenblum Rubens , Isaak Elis Mueller , Gianluca Selvaggio , Paul Miller , Dean Falb , Vincent Isabella , Jonathan Kotula
IPC: A61K35/741 , C07K16/24 , C07K14/54 , A61K39/395 , A61K38/20 , A61K36/064 , A61K31/122 , C12N15/70 , A61K9/00
CPC classification number: A61K35/741 , A61K9/0053 , A61K31/122 , A61K35/74 , A61K36/064 , A61K38/19 , A61K38/204 , A61K38/2066 , A61K39/3955 , C07K14/5428 , C07K16/241 , C12N15/63 , C12N15/70 , G01N33/573 , G01N33/6863
Abstract: Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.
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公开(公告)号：US20170204399A1
公开(公告)日：2017-07-20
申请号：US15324487
申请日：2015-08-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Fahim Farzadfard
CPC classification number: C12N15/1024 , C12N9/1276 , C12N9/22 , C12N15/102 , C12N15/63 , C12N15/635 , C12Y207/07049
Abstract: Aspects of the present disclosure provide synthetic-biology platforms for in vivo genome editing, which enable the use of live cell genomes as “tape recorders” for long-term recording of event histories and analog memories.
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Patent Agency Ranking
公开(公告)号：US09315806B2
公开(公告)日：2016-04-19
申请号：US14411628
申请日：2013-06-28
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Allen Cheng
CPC classification number: C12N15/1065 , C12N15/1027 , C12N15/1079 , C12N15/66 , C12Q1/6869 , G01N2035/00752 , C12Q2525/131 , C12Q2563/179
Abstract: The invention relates to methods and compositions that enable the rapid generation of high-order combinations of genetic elements, and that provide a barcoded basis for rapid characterization of the specific combination of genetic elements encoded within a single cell or in a pooled population.
Abstract translation: 本发明涉及能够快速产生遗传元件的高阶组合的方法和组合物，并且提供了用于快速表征在单个细胞或合并的群体内编码的遗传元件的特定组合的条形码基础的方法和组合物。
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公开(公告)号：US11718860B2
公开(公告)日：2023-08-08
申请号：US16493340
申请日：2018-03-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Lior Nissim , Ming-Ru Wu
IPC: A01N63/00 , A61K39/245 , C07H21/04 , C12N15/85 , A61K35/763 , C12N15/86
CPC classification number: C12N15/85 , A61K35/763 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , C12N2830/008
Abstract: Synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells) are described. The synthetic promoters may be used to drive expression of gene(s) of interest in a specific cell type or during a specific cellular state. These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.
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公开(公告)号：US20210171977A1
公开(公告)日：2021-06-10
申请号：US16493340
申请日：2018-03-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Lior Nissim , Ming-Ru Wu
IPC: C12N15/85 , C12N15/86 , A61K35/763
Abstract: Aspects of the present disclosure provide synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells). These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.
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公开(公告)号：US20210115413A1
公开(公告)日：2021-04-22
申请号：US17253946
申请日：2019-06-20
Applicant: Massachusetts Institute of Technology , Pfizer Inc.
Inventor： Michelle Chang , Leonid A. Gaydukov , Giyoung Jung , Nevin M. Summers , Timothy Kuan-Ta Lu , Ron Weiss , John Scarcelli , Richard Cornell , Jeffrey Marshall , Bruno Figueroa , Wen Allen Tseng
Abstract: Disclosed herein are methods of generating proteoglycans with distinct glycan structures in engineered, non-naturally occurring eukaryotic cells. These methods make accessible a dynamic range of protein glycosylation. Compositions of engineered, non-naturally occurring cells capable of generating these proteoglycans are also disclosed herein.
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公开(公告)号：US10752904B2
公开(公告)日：2020-08-25
申请号：US15497703
申请日：2017-04-26
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu
IPC: C12N15/09 , C12N15/63 , C12N15/85 , C12N15/90 , C12Q1/6876 , C12N15/10 , A01K67/027 , C12N9/12 , C12N9/22
Abstract: Provided herein are genetic constructs comprising genetic perturbation cassettes and methods of using such to assess the timing and order of gene expression.
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