Invention Grant
- Patent Title: Detection of a posttranslationally modified polypeptide by a bivalent binding agent
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Application No.: US15465439Application Date: 2017-03-21
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Publication No.: US10982007B2Publication Date: 2021-04-20
- Inventor: Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
- Applicant: Roche Diagnostics Operations, Inc.
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Agency: Stinson LLP
- Priority: EP10196687 20101223,EP11173832 20110713
- Main IPC: C07K16/46
- IPC: C07K16/46 ; G01N33/531
Abstract:
A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.
Public/Granted literature
- US20170275381A1 DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BIVALENT BINDING AGENT Public/Granted day:2017-09-28
Information query
