A memory subsystem enables per device addressability (PDA) to target configuration commands to one of multiple memory devices that share a select line or buffer devices that share an enable line. The system includes a host and multiple memory devices that can be coupled over a command bus and a data bus. The devices include a configuration or mode register to store a value to indicate whether PDA enumeration is enabled. When enabled, the host can provide an enumeration identifier (ID) command via the command bus with a signal via the data bus to assign an enumeration ID. After assignment of the enumeration ID, the host can send PDA commands via the command bus with the enumeration ID, without a signal on the data bus. Devices only process PDA commands that match their assigned enumeration ID, enabling the setting of device-specific configuration settings without needing to use the data bus on every PDA command.