发明授权
- 专利标题： Methods for generating bispecific shark variable antibody domains and use thereof
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申请号： US15523888申请日： 2015-10-21
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公开(公告)号： US11001640B2公开(公告)日： 2021-05-11
- 发明人: Stefan Becker , Bjoern Hock , Stefan Zielonka , Harald Kolmar , Martin Empting
- 申请人： Merck Patent GmbH
- 申请人地址： DE Darmstadt
- 专利权人： Merck Patent GmbH
- 当前专利权人： Merck Patent GmbH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Goodwin Procter LLP
- 优先权： EP14003700 20141103
- 国际申请： PCT/EP2015/002086 WO 20151021
- 国际公布： WO2016/070959 WO 20160512
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/30 ; C07K16/00 ; C12N15/81 ; A61K39/395
摘要：
The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.
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