公开(公告)号：US11572395B2

公开(公告)日：2023-02-07

申请号：US16648677

申请日：2018-09-20

申请人： MERCK PATENT GMBH

发明人： Anne Gigout ,  Christian Brenneis ,  Thomas Rysiok ,  Stefan Zielonka

IPC分类号： A61K38/18 ,  C07K14/50 ,  A61P19/02 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

摘要： The present invention relates to new fusion proteins comprising an FGF-18 moiety fused to an anti-NGF moiety. Said fusion protein can be used for the treatment of a cartilage disorder such as osteoarthritis or cartilage injury.

公开(公告)号：US11001640B2

公开(公告)日：2021-05-11

申请号：US15523888

申请日：2015-10-21

申请人： Merck Patent GmbH

发明人： Stefan Becker ,  Bjoern Hock ,  Stefan Zielonka ,  Harald Kolmar ,  Martin Empting

IPC分类号： A61K39/00 ,  C07K16/30 ,  C07K16/00 ,  C12N15/81 ,  A61K39/395

摘要： The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.

公开(公告)号：US20230287082A1

公开(公告)日：2023-09-14

申请号：US18024057

申请日：2021-08-31

申请人： Merck Patent GmbH

发明人： Stefan Zielonka ,  Lars Toleikis ,  Simon Krah ,  Lukas Pekar

IPC分类号： C07K14/705

CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K2319/30

摘要： B7-H6-based compounds disclosed herein have favorable characteristics. Pharmaceutical compositions containing such a compound, the use of such compounds, and treatment with such pharmaceutical compositions are also disclosed. Methods for preparing a compound with an increased affinity for NKp30 are provided.

公开(公告)号：US20180171020A1

公开(公告)日：2018-06-21

申请号：US15523888

申请日：2015-10-21

申请人： Merck Patent GmbH

发明人： Stefan Becker ,  Bjoern Hock ,  Stefan Zielonka ,  Harald Kolmar ,  Martin Empting

IPC分类号： C07K16/30 ,  C12N15/81

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/30 ,  C12N15/81

摘要： The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.