Invention Grant
- Patent Title: Neuro-stem cell stimulation and growth enhancement with implantable nanodevice
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Application No.: US16691993Application Date: 2019-11-22
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Publication No.: US11013908B2Publication Date: 2021-05-25
- Inventor: Steven J. Holmes , Qinghuang Lin , Emily R. Kinser , Nathan P. Marchack , Roy R. Yu
- Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
- Applicant Address: US NY Armonk
- Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
- Current Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
- Current Assignee Address: US NY Armonk
- Agency: Tutunjian & Bitetto, P.C.
- Agent L. Jeffrey Kelly
- Main IPC: A61N1/04
- IPC: A61N1/04 ; A61K38/18 ; A61B5/00 ; B82Y15/00 ; A61N1/375 ; A61N1/05 ; A61N1/08

Abstract:
A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
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