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公开(公告)号：US11077475B2
公开(公告)日：2021-08-03
申请号：US15602363
申请日：2017-05-23
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Steven J. Holmes , Emily R. Kinser , Qinghuang Lin , Nathan P. Marchack , Roy R. Yu
Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.
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公开(公告)号：US10736997B2
公开(公告)日：2020-08-11
申请号：US15927419
申请日：2018-03-21
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Stacey M. Gifford , Huan Hu , Emily R. Kinser , Roy R. Yu , Sufi Zafar
IPC: A61L27/30 , A61L31/06 , A61L31/08 , B28B3/00 , H01L21/00 , A61L31/16 , B81C1/00 , A61L27/06 , A61L27/50 , A61L27/34 , A61L31/10 , B82B3/00
Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
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公开(公告)号：US10583282B2
公开(公告)日：2020-03-10
申请号：US15811023
申请日：2017-11-13
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Steven J. Holmes , Qinghuang Lin , Emily R. Kinser , Nathan P. Marchack , Roy R. Yu
Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
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公开(公告)号：US20200009369A1
公开(公告)日：2020-01-09
申请号：US16573644
申请日：2019-09-17
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Steven J. Holmes , Qinghuang Lin , Emily R. Kinser , Nathan P. Marchack , Roy R. Yu
Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.
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公开(公告)号：US20190056344A1
公开(公告)日：2019-02-21
申请号：US16169654
申请日：2018-10-24
Applicant: International Business Machines Corporation
Inventor： Emily R. Kinser
Abstract: Methods for forming an electrode structure, which can be used as a biosensor, are provided in which the electrode structure has non-random topography located on one surface of an electrode base. In some embodiments, an electrode structure is obtained that contains no interface between the non-random topography of the electrode structure and the electrode base of the electrode structure. In other embodiments, electrode structures are obtained that have an interface between the non-random topography of the electrode structure and the electrode base of the electrode structure.
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Patent Agency Ranking
公开(公告)号：US20190056343A1
公开(公告)日：2019-02-21
申请号：US16169635
申请日：2018-10-24
Applicant: International Business Machines Corporation
Inventor： Emily R. Kinser
Abstract: Methods for forming an electrode structure, which can be used as a biosensor, are provided in which the electrode structure has non-random topography located on one surface of an electrode base. In some embodiments, an electrode structure is obtained that contains no interface between the non-random topography of the electrode structure and the electrode base of the electrode structure. In other embodiments, electrode structures are obtained that have an interface between the non-random topography of the electrode structure and the electrode base of the electrode structure.
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公开(公告)号：US10161898B2
公开(公告)日：2018-12-25
申请号：US15419524
申请日：2017-01-30
Applicant: International Business Machines Corporation
Inventor： Emily R. Kinser
Abstract: Methods for forming an electrode structure, which can be used as a biosensor, are provided in which the electrode structure has non-random topography located on one surface of an electrode base. In some embodiments, an electrode structure is obtained that contains no interface between the non-random topography of the electrode structure and the electrode base of the electrode structure. In other embodiments, electrode structures are obtained that have an interface between the non-random topography of the electrode structure and the electrode base of the electrode structure.
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公开(公告)号：US20180339155A1
公开(公告)日：2018-11-29
申请号：US15808137
申请日：2017-11-09
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Hariklia Deligianni , Bruce B. Doris , Steven J. Holmes , Emily R. Kinser , Qinghuang Lin , Roy R. Yu
IPC: A61N1/36 , A61B5/06 , A61B5/00 , A61B5/145 , H01L23/58 , H01L21/283 , H01L21/3213 , A61N1/05
Abstract: A sensing and treatment device includes an array of metal nanorod electrodes formed on a substrate, the array including first electrodes for sensing, and second electrodes for electrical pulsation. A data processing system is configured to monitor a parameter using the first electrodes and to activate the electrical pulsation in the second electrodes in accordance with a reading of the parameter.
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公开(公告)号：US20180272045A1
公开(公告)日：2018-09-27
申请号：US15464386
申请日：2017-03-21
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Stacey M. Gifford , Huan Hu , Emily R. Kinser , Roy R. Yu , Sufi Zafar
CPC classification number: A61L31/16 , A61L27/06 , A61L27/306 , A61L27/34 , A61L27/50 , A61L31/06 , A61L31/088 , A61L31/10 , A61L2300/406 , A61L2300/606 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61L2420/08 , B81B2203/0361 , B81B2207/056 , B81C1/00206 , B82B3/0019 , B82B3/0033
Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
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公开(公告)号：US20180143140A1
公开(公告)日：2018-05-24
申请号：US15858472
申请日：2017-12-29
Applicant: International Business Machines Corporation
Inventor： Emily R. Kinser , Roy R. Yu
CPC classification number: G01N21/658 , G01J3/02 , G01J3/18 , G01J3/44 , G01N21/65
Abstract: Surface enhanced Raman spectroscopy is employed to obtain chemical data with respect to cells while electrophysiological data relating to cell membranes is obtained using the patch clamp technique. A SERS-facilitating assembly is coupled to a micropipette and is used in conjunction with a monochromatic light source for generating scattered light. Surface enhanced Raman spectroscopy is employed to obtain the chemical data. Electrophysiological data is obtained using the same micropipette to perform the patch clamp technique.
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