Invention Grant
- Patent Title: Mutated immunoglobulin-binding polypeptides
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Application No.: US15900419Application Date: 2018-02-20
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Publication No.: US11136359B2Publication Date: 2021-10-05
- Inventor: Gustav Rodrigo , Mats Ander , Tomas Bjorkman , Goran Bauren
- Applicant: Cytiva BioProcess R&D AB
- Applicant Address: SE Uppsala
- Assignee: Cytiva BioProcess R&D AB
- Current Assignee: Cytiva BioProcess R&D AB
- Current Assignee Address: SE Uppsala
- Agency: Eversheds Sutherland (US) LLP
- Priority: SE1350859-3 20130710,SE1350860-1 20130710
- Main IPC: C07K14/31
- IPC: C07K14/31 ; B01D15/38 ; B01J20/286 ; B01J20/32 ; C07K1/22 ; C07K14/745 ; C07K16/00
Abstract:
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Public/Granted literature
- US20180244729A1 MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES Public/Granted day:2018-08-30
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