Invention Grant
- Patent Title: Method for purifying active polypeptides or immunoconjugates
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Application No.: US16786634Application Date: 2020-02-10
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Publication No.: US11136396B2Publication Date: 2021-10-05
- Inventor: Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
- Applicant: MedImmune Limited
- Applicant Address: GB Cambridge
- Assignee: MedImmune Limited
- Current Assignee: MedImmune Limited
- Current Assignee Address: GB Cambridge
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K49/00 ; A61K39/395 ; C07K16/28 ; B01D15/16 ; B01D15/36 ; B01J41/14 ; B01J41/20 ; A61K47/68 ; C07K1/18 ; C07K17/02 ; A61K47/02
Abstract:
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
Public/Granted literature
- US20200231680A1 METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES Public/Granted day:2020-07-23
Information query
