公开(公告)号：US11136396B2

公开(公告)日：2021-10-05

申请号：US16786634

申请日：2020-02-10

Applicant: MedImmune Limited

Inventor： Thomas Linke ,  William K. Wang ,  Ambarish Shah ,  Hasige Sathish ,  Alan Hunter ,  Christopher Thompson

IPC: A61K39/00 ,  A61K49/00 ,  A61K39/395 ,  C07K16/28 ,  B01D15/16 ,  B01D15/36 ,  B01J41/14 ,  B01J41/20 ,  A61K47/68 ,  C07K1/18 ,  C07K17/02 ,  A61K47/02

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

公开(公告)号：US10556955B2

公开(公告)日：2020-02-11

申请号：US16124441

申请日：2018-09-07

Applicant: MedImmune Limited

Inventor： Thomas Linke ,  William K. Wang ,  Ambarish Shah ,  Hasige Sathish ,  Alan Hunter ,  Christopher Thompson

IPC: A61K49/00 ,  A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  B01D15/16 ,  B01D15/36 ,  B01J41/14 ,  B01J41/20 ,  A61K47/68 ,  C07K1/18 ,  C07K17/02 ,  A61K47/02

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.