The present invention relates to poly(alkylene terephthalate) polyesters having long poly-methylene segments and their use in a wide variety of applications. Particularly, said PAT polyesters are used in biotechnological or biomedical applications, wherein the extent of cell adhesion, cell growth or cell interaction, in particular endothelial cells, depends on the odd or even number of carbon atoms in the aliphatic segments. Also provided are methods for the preparation of poly(alkylene terephthalates) (PAT) having long poly-methylene segments, wherein the bifunctional monomers, in particular terephthalic acid (or a derivative thereof) and an aliphatic diol, are dissolved in a solvent and the polycondensation reaction takes place in solution.